The winners of Widnes' Liverpool Senior Cup second round tie against Marine will entertain Everton in the quarter-finals.
The Whites will have to dispatch the Mariners on 9th January if they are to be rewarded with a plum home tie against a youthful Toffees squad in the last eight.
Marine are the current holders of the competition while Everton are the competition's most successful club having lifted the trophy on 46 different occasions.
The full quarter-final draw is as follows.
Warrington Rylands v Tranmere Rovers
City of Liverpool v Runcorn Linnets
Prescot Cables v Bootle
Marine/Widnes v Everton